hydralazine drug class ccb
Hydralazine and minoxidil are 2 common agents in this class. Strategy Description A Start one drug titrate to maximum dose and then add a second drug.
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Although both are effective antihypertensive medications their side-effect profiles preclude their use as initial monotherapy agents or as first-line therapies and make them useful only as add-on therapy especially in.
. Hypertension HTN is considered one of the leading causes of increased cardiovascular disease. Requires multiple daily doses Consider using both a nondihydropyridine and a dihydropyridine CCB. Calcium channel blocker CCB At blood pressure goal.
However given the biologically plausible off-target effects of SGLT-2 inhibitors including impairment of the sodium-hydrogen exchanger which manages cellular pH in ischemiareperfusion it is reasonable to avoid this drug class in patients at risk for lower limb. Add clonidine Catapres guanfacine Tenex reserpine or hydralazine Apresoline. Both directly relax vascular smooth muscle primarily arterioles through different mechanisms of action.
Maintaining systolic blood pressure less than 130 mm Hg demonstrably prevents complications in patients with heart failure diabetes coronary artery disease stroke and other cardiovascular diseases. Lowering blood pressure does reduce cardiovascular risks. Currently it is unknown whether the amputation risk is specific to canagliflozin or extends to other drugs in this class.
Initial combination therapy is. B Start one drug then add a second drug before achieving max dose of first C Begin 2 drugs at same time as separate pills or combination pill.
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